Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.58 |
| ▸ | GSK3B | P49841 | 5/20 | 0.58 |
| ▸ | MAP3K14 | Q99558 | 4/20 | 0.58 |
| ▸ | CLK1 | P49759 | 3/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.58 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20030496 | 0.80 | DYRK1A (0.72) | DYRK1AGSK3BMAP3K14CLK1CDK5 | |
| SCHEMBL145566 | 0.78 | GSK3B (0.70) | DYRK1AGSK3BMAP3K14CLK1CDK5 | |
| SCHEMBL29488162 | 0.75 | GSK3B (1.00) | DYRK1AGSK3BMAP3K14CLK1CDK5 | |
| SCHEMBL573402 | 0.75 | GSK3B (1.00) | DYRK1AGSK3BMAP3K14CLK1CDK5 | |
| SCHEMBL28230580 | 0.73 | CLK1 (0.67) | DYRK1AGSK3BMAP3K14CLK1CDK5 | |
| SCHEMBL4564892 | 0.72 | DYRK1A (0.68) | DYRK1AGSK3BMAP3K14CLK1CDK5 | |
| SCHEMBL29534011 | 0.69 | DYRK1A (0.68) | DYRK1AGSK3BMAP3K14CLK1CDK5 | |
| SCHEMBL3818537 | 0.69 | DYRK1A (0.68) | DYRK1AGSK3BMAP3K14CLK1CDK5 | |
| SCHEMBL7496465 | 0.69 | DYRK1A (0.63) | DYRK1AGSK3BMAP3K14CLK1CDK5 | |
| SCHEMBL20691186 | 0.69 | EIF2AK2 (0.67) | DYRK1AGSK3BMAP3K14CLK1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836194-A1 | 4- (1H-INDOL-3-YL) -PYRIMIDIN-2-YLAMINE DERIVATES AND THEIR USE IN THERAPY | Cyclacel Limited (GB) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006075152-A1 | 4- (1H-INDOL-3-YL) -PYRIMIDIN-2-YLAMINE DERIVATES AND THEIR USE IN THERAPY | CYCLACEL LIMITED (GB) | 2006-07-20 | — | — | WO | disclosed |