Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.70 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.70 |
| ▸ | CLK1 | P49759 | 4/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.70 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20030496 | 0.88 | DYRK1A (0.72) | GSK3BCDK5CDK5R1CLK1DYRK1A | |
| SCHEMBL573402 | 0.82 | GSK3B (1.00) | GSK3BCDK5CDK5R1CLK1DYRK1A | |
| SCHEMBL29488162 | 0.82 | GSK3B (1.00) | GSK3BCDK5CDK5R1CLK1DYRK1A | |
| SCHEMBL28230580 | 0.81 | CLK1 (0.67) | GSK3BCDK5CDK5R1CLK1DYRK1A | |
| SCHEMBL15876511 | 0.80 | ALDH1A1 (0.46) | GSK3BCDK5CDK5R1CLK1DYRK1A | |
| SCHEMBL5314928 | 0.78 | DYRK1A (0.58) | GSK3BCDK5CDK5R1CLK1DYRK1A | |
| SCHEMBL21850038 | 0.77 | ALDH1A1 (0.52) | GSK3BCDK5CDK5R1CLK1DYRK1A | |
| SCHEMBL30736362 | 0.77 | ALDH1A1 (0.52) | GSK3BCDK5CDK5R1CLK1DYRK1A | |
| SCHEMBL29534011 | 0.77 | DYRK1A (0.68) | GSK3BCDK5CDK5R1CLK1DYRK1A | |
| SCHEMBL3818537 | 0.77 | DYRK1A (0.68) | GSK3BCDK5CDK5R1CLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221455-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | Verva Pharmaceuticals, Inc. (AU) | 2014-08-07 | — | — | US | disclosed |
| US-20120059047-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | VERVA PHARMACEUTICALS PTY LTD (AU) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059047-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | FGF1, FABP4, FGF2 | GSK3B 341/4885CDK5 1744/4885CDK5R1 1738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.