Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314825 | 0.89 | MAPT (0.66) | MAPTLMNAHTTTP53MEN1 | |
| SCHEMBL5319016 | 0.89 | MAPT (0.83) | MAPTLMNAHTTTP53MEN1 | |
| SCHEMBL4876016 | 0.82 | MAPT (0.59) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL5312315 | 0.80 | MAPT (0.55) | MAPTLMNAHTTTP53MEN1 | |
| SCHEMBL4034628 | 0.80 | RAB9A (0.61) | MAPTLMNATP53KMT2ARXFP1 | |
| SCHEMBL5783405 | 0.79 | TRPV1 (0.76) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL14419311 | 0.78 | MAPT (0.52) | MAPTLMNAHTTTP53MEN1 | |
| SCHEMBL14847474 | 0.78 | RAB9A (0.65) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL15228759 | 0.77 | RAB9A (0.62) | MAPTLMNATP53KMT2ARXFP1 | |
| SCHEMBL4873851 | 0.77 | MAPT (0.55) | MAPTLMNAHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067757-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | claimed |
| WO-2007067757-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | disclosed |