Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 18/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.81 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313435 | 0.92 | OPRD1 (0.83) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL5316799 | 0.90 | OPRD1 (1.00) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL5314784 | 0.90 | OPRD1 (1.00) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL5312960 | 0.90 | OPRD1 (1.00) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL5316980 | 0.89 | OPRD1 (0.81) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL5316974 | 0.86 | OPRD1 (0.83) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL5332875 | 0.86 | OPRD1 (0.79) | OPRD1KCNH2 | |
| SCHEMBL5316820 | 0.85 | OPRD1 (0.78) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL14530257 | 0.85 | OPRD1 (0.78) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL5312233 | 0.84 | OPRD1 (0.76) | OPRD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | claimed |
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |