Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.38 |
| ▸ | CTSD | P07339 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914082 | 0.90 | MAPK14 (0.39) | MAPK14ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL5914118 | 0.83 | MAPK14 (0.42) | MAPK14ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL5914162 | 0.83 | HPGDS (0.40) | MAPK14ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL5914169 | 0.83 | HPGDS (0.40) | MAPK14ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL5914203 | 0.81 | GRM2 (0.41) | MAPK14ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL5914202 | 0.81 | GRM2 (0.41) | MAPK14ALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL5913871 | 0.80 | MAPK14 (0.38) | MAPK14MAPK1KDR | |
| SCHEMBL5913877 | 0.80 | MAPK14 (0.38) | MAPK14MAPK1KDR | |
| SCHEMBL5314959 | 0.78 | MAPK14 (0.40) | MAPK14ALDH1A1KDR | |
| SCHEMBL5314967 | 0.78 | MAPK14 (0.40) | MAPK14ALDH1A1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |