Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2966221 | 0.87 | KCNH2 (0.70) | KCNH2KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL2966219 | 0.87 | KCNH2 (0.70) | KCNH2KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL2969492 | 0.86 | KCNH2 (0.66) | KCNH2KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL2960609 | 0.86 | KCNH2 (0.62) | KCNH2KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL2956759 | 0.84 | KCNH2 (0.62) | KCNH2KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL4137999 | 0.83 | KCNH2 (0.65) | KCNH2KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL2968092 | 0.83 | KCNH2 (0.60) | KCNH2KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL2964698 | 0.83 | KCNH2 (0.64) | KCNH2KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL6151398 | 0.83 | KCNH2 (0.64) | KCNH2KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL3130741 | 0.82 | KCNH2 (0.68) | KCNH2KDM4EALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |