Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317598 | 0.95 | KCNA5 (0.50) | PRKAA2KCNA5KCNH2MMP3CXCR3 | |
| SCHEMBL5343106 | 0.90 | KCNH2 (0.48) | PRKAA2KCNA5KCNH2MMP3ALDH1A1 | |
| SCHEMBL5316242 | 0.85 | ABCB1 (0.49) | KCNA5KCNH2MMP3LMNAPKM | |
| SCHEMBL5318090 | 0.85 | KCNH2 (0.52) | KCNA5KCNH2LMNAPKM | |
| SCHEMBL5314851 | 0.85 | POLB (0.53) | PRKAA2DPP4DPP8ALDH1A1CYP3A4 | |
| SCHEMBL5317202 | 0.84 | KCNH2 (0.60) | PRKAA2KCNA5KCNH2MMP3 | |
| SCHEMBL5315943 | 0.82 | KCNH2 (0.51) | PRKAA2KCNA5KCNH2ALDH1A1POLB | |
| SCHEMBL5317191 | 0.82 | POLB (0.44) | KCNA5KCNH2DPP4DPP8ALDH1A1 | |
| SCHEMBL5318355 | 0.81 | POLB (0.60) | DPP4DPP8ALDH1A1POLBMAPT | |
| SCHEMBL5315856 | 0.81 | POLB (0.49) | ALDH1A1HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |