Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5340709 | 0.91 | KCNH2 (0.41) | POLBCYP2C19LMNASMN1; SMN2TSHR | |
| SCHEMBL5314851 | 0.89 | POLB (0.53) | POLBCYP2C19DPP4DPP8TSHR | |
| SCHEMBL5314736 | 0.86 | KMT2A (0.50) | POLBSMN1; SMN2KMT2A | |
| SCHEMBL5315856 | 0.85 | POLB (0.49) | POLBTSHRHTTALDH1A1KMT2A | |
| SCHEMBL5318355 | 0.85 | POLB (0.60) | POLBDPP4DPP8LMNATSHR | |
| SCHEMBL5314874 | 0.85 | POLB (0.54) | POLBLMNASMN1; SMN2TSHRHTT | |
| SCHEMBL5315911 | 0.84 | POLB (0.46) | POLBCYP2C19DPP4SMN1; SMN2ALDH1A1 | |
| SCHEMBL5317559 | 0.82 | CD274 (0.47) | SMN1; SMN2KCNH2GPR6KMT2A | |
| SCHEMBL5315852 | 0.82 | PRKAA2 (0.47) | POLBCYP2C19DPP4DPP8LMNA | |
| SCHEMBL5316192 | 0.81 | HTT (0.52) | POLBTSHRHTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |