Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.62 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260199 | 0.89 | KCNH2 (0.76) | KCNH2 | |
| SCHEMBL14498816 | 0.89 | KCNH2 (0.63) | KCNH2HSF1 | |
| SCHEMBL5260215 | 0.80 | KCNH2 (0.76) | KCNH2 | |
| SCHEMBL5265007 | 0.80 | KCNH2 (0.63) | KCNH2 | |
| SCHEMBL5261624 | 0.78 | KCNH2 (0.79) | KCNH2 | |
| SCHEMBL14498785 | 0.78 | KCNH2 (0.79) | KCNH2 | |
| SCHEMBL5263867 | 0.77 | KCNH2 (0.56) | KCNH2 | |
| SCHEMBL5264690 | 0.76 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL5262423 | 0.76 | KCNH2 (0.59) | KCNH2 | |
| SCHEMBL5260170 | 0.75 | KCNH2 (0.55) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399443-B1 | NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2007-12-12 | — | — | EP | claimed |