Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5913955 | 0.90 | PDE4B (0.51) | PDE4BTYRO3MAPK8GBA1HIF1A | |
| SCHEMBL5264243 | 0.84 | ALDH1A1 (0.48) | TYRO3MAPK8LMNATDP1JAK3 | |
| SCHEMBL5914085 | 0.76 | PDE4B (0.52) | PDE4BTYRO3MAPK8GBA1JAK3 | |
| SCHEMBL5914236 | 0.75 | PDE4B (0.55) | PDE4BTYRO3GBA1HIF1AJAK3 | |
| SCHEMBL5261679 | 0.72 | PDE4B (0.50) | PDE4BTYRO3GBA1JAK3JAK2 | |
| SCHEMBL14656783 | 0.67 | SYK (0.72) | TYRO3MAPK8JAK3 | |
| SCHEMBL29761494 | 0.67 | SYK (0.72) | TYRO3MAPK8JAK3 | |
| SCHEMBL5914293 | 0.66 | OGA (0.47) | GBA1LMNAHIF1ATLR9OGA | |
| SCHEMBL13743048 | 0.66 | SMN1; SMN2 (0.48) | GBA1HIF1AJAK3 | |
| SCHEMBL5089075 | 0.66 | OGA (0.53) | GBA1LMNAHIF1AOGAMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |