Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | FABP7 | O15540 | 1/20 | 0.59 |
| ▸ | FABP3 | P05413 | 1/20 | 0.59 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3166260 | 0.91 | ELANE (0.72) | ELANEKMT2ASMN1; SMN2HTTTDP1 | |
| SCHEMBL12370828 | 0.88 | ELANE (0.73) | ELANEKMT2ASMN1; SMN2HTTTDP1 | |
| SCHEMBL3079124 | 0.88 | ELANE (0.73) | ELANEKMT2ASMN1; SMN2HTTTDP1 | |
| SCHEMBL3193624 | 0.88 | ELANE (0.73) | ELANEKMT2ASMN1; SMN2HTTTDP1 | |
| SCHEMBL12642500 | 0.88 | ELANE (0.73) | ELANEKMT2ASMN1; SMN2HTTTDP1 | |
| SCHEMBL525974 | 0.88 | ELANE (0.73) | ELANEKMT2ASMN1; SMN2HTTTDP1 | |
| Hydrochloric Acid SCHEMBL3866426 | 0.86 | ELANE (0.71) | ELANEKMT2ASMN1; SMN2HTTTDP1 | |
| SCHEMBL11823665 | 0.86 | KMT2A (0.83) | ELANEKMT2ASMN1; SMN2HTTTDP1 | |
| SCHEMBL27676346 | 0.85 | ELANE (0.70) | ELANEKMT2ASMN1; SMN2HTTTDP1 | |
| SCHEMBL21185911 | 0.84 | HTT (0.61) | ELANEKMT2ASMN1; SMN2HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100475813-C | 4-oxo-1- (3-substituted phenyl) -1, 4-dihydro-1, 8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors | MERCK FROSST CANADA INC (CA) | 2009-04-08 | — | — | CN | claimed |
| EP-1633306-A4 | USE OF PHOSPHATASE INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | MERCK & CO INC (US) | 2007-05-16 | — | — | EP | claimed |
| EP-1633306-A2 | USE OF PHOSPHATASE INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | Merck & Co., Inc. (US) | 2006-03-15 | — | — | EP | claimed |
| CN-1738819-A | 4-oxo-1- (3-substituted phenyl) -1, 4-dihydro-1, 8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors | MERCK FROSST CANADA INC (CA) | 2006-02-22 | — | — | CN | claimed |
| WO-2004105698-A2 | USE OF PHOSPHATASE INHIBITORS AS ADJUNCT THERAPY FOR PSYCHIATRIC DISORDERS | MERCK & CO., INC. (US) | 2004-12-09 | — | — | WO | claimed |
| CN-103596566-A | Polycyclic LPA1 antagonists and uses thereof | AMIRA PHARMACEUTICALS INC | 2014-02-19 | — | — | CN | disclosed |
| CN-102459204-A | Polycyclic antagonists of lysophosphatidic acid receptors | AMIRA PHARMACEUTICALS INC | 2012-05-16 | — | — | CN | disclosed |
| CN-100475813-C | 4-oxo-1- (3-substituted phenyl) -1, 4-dihydro-1, 8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors | MERCK FROSST CANADA INC (CA) | 2009-04-08 | — | — | CN | disclosed |
| CN-1738819-A | 4-oxo-1- (3-substituted phenyl) -1, 4-dihydro-1, 8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors | MERCK FROSST CANADA INC (CA) | 2006-02-22 | — | — | CN | disclosed |
| EP-1565464-A1 | 4-OXO-1-(3-SUBSTITUTED PHENYL-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDE PHOSPHODIESTERASE-4 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048374-A1 | 4-OXO-1-(3-SUBSTITUTED PHENYL-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-06-10 | — | — | WO | disclosed |