Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27942442 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EGLAHTR4PRMT1 | |
| SCHEMBL5318231 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2KDM4EGLAHTR4PRMT1 | |
| SCHEMBL2946654 | 0.79 | HTR4 (0.45) | SMN1; SMN2KDM4EHTR4KMT2AXDH | |
| SCHEMBL2944408 | 0.79 | HTR4 (0.50) | HTR4LMNA | |
| SCHEMBL5316783 | 0.77 | HTR4 (0.47) | KDM4EGAAHTR4MEN1KMT2A | |
| SCHEMBL7413113 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2KDM4EGLA | |
| SCHEMBL24104857 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EGLACA12CA1 | |
| SCHEMBL31156007 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EMAPTAKR1C4AKR1C3 | |
| SCHEMBL10792029 | 0.71 | KDM4E (0.48) | SMN1; SMN2KDM4ECA12CA1CA2 | |
| SCHEMBL9053612 | 0.70 | KDM4E (0.42) | SMN1; SMN2KDM4EGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007068739-A1 | 4-AMINO-BENZAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL, NEUROLOGICAL AND CARDIOVASCULAR DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | WO | disclosed |