Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | STAT6 | P42226 | 4/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | BLK | P51451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264926 | 0.89 | STAT6 (0.44) | JAK3STAT6MKNK1MKNK2GBA1 | |
| SCHEMBL5261679 | 0.79 | PDE4B (0.50) | JAK3STAT6GBA1JAK2JAK1 | |
| SCHEMBL5914124 | 0.75 | OGA (0.48) | MKNK1MKNK2GBA1OGACCNA2 | |
| SCHEMBL5914225 | 0.75 | JAK3 (0.54) | JAK3STAT6JAK2JAK1TYRO3 | |
| SCHEMBL5914085 | 0.71 | PDE4B (0.52) | JAK3STAT6MKNK1MKNK2GBA1 | |
| SCHEMBL5913970 | 0.70 | GBA1 (0.45) | MKNK1MKNK2GBA1OGA | |
| SCHEMBL5262434 | 0.69 | GBA1 (0.42) | MKNK1MKNK2GBA1OGACCNA2 | |
| SCHEMBL5263806 | 0.67 | MAPK14 (0.42) | MAPK14 | |
| SCHEMBL5913967 | 0.67 | HTR7 (0.48) | MKNK1MKNK2OGACCNA2CDK2 | |
| SCHEMBL5914395 | 0.66 | CYP1A2 (0.55) | MKNK1MKNK2GBA1OGACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | claimed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | claimed |