Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | LCK | P06239 | 4/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 4/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | PRKDC | P78527 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220421 | 0.90 | PDGFRB (0.54) | PDGFRBPDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL5315885 | 0.87 | PDGFRB (0.51) | PDGFRBPDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL1940704 | 0.85 | PDGFRB (0.51) | PDGFRBPDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL1940486 | 0.84 | PDGFRB (0.51) | PDGFRBPDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL1941196 | 0.84 | NTRK1 (0.59) | PDGFRBPDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL1940773 | 0.84 | NTRK1 (0.55) | PDGFRBPDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL5350777 | 0.83 | PDGFRB (0.49) | PDGFRBPDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL6223876 | 0.83 | PDGFRB (0.53) | PDGFRBPDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL1941531 | 0.82 | PDGFRB (0.66) | PDGFRBPDPK1NTRK1NTRK2NTRK3 | |
| SCHEMBL1941303 | 0.82 | PDGFRB (0.51) | PDGFRBPDPK1NTRK1NTRK2NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287719-A1 | Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea | PFIZER INC | 2007-12-13 | — | — | US | disclosed |
| US-20070287719-A1 | Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea | PFIZER INC | 2007-12-13 | — | — | US | disclosed |
| US-20070287719-A1 | Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea | PFIZER INC | 2007-12-13 | — | — | US | disclosed |
| WO-2007066189-A2 | SALTS, PRODRUGS AND FORMULATIONS OF 1-[5-(4-AMINO-7-ISOPROPYL-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONYL)-2-METHOXY-PHENYL]-3-(2,4-DICHLORO-PHENYL)-UREA | PFIZER PRODUCTS INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| EP-1578751-A1 | PYRROLOPYRIMIDINE DERIVATIVES | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | PFIZER INC | 2005-02-17 | — | — | US | disclosed |
| WO-2004056830-A1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | CCNA1, CCNT1, TP53 | PDGFRB 2465/4885PDPK1 832/4885NTRK1 4135/4885 |
| US-20070287719-A1 | Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea | CDKN1A, DPYD, SLC14A1 | PDGFRB 3365/4885PDPK1 1357/4885NTRK1 4755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.