Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12868340 | 0.91 | LMNA (0.79) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL11756284 | 0.90 | LMNA (0.63) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL13049444 | 0.86 | SMN1; SMN2 (0.65) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL3722389 | 0.85 | BAZ2B (0.58) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL1867588 | 0.84 | BAZ2B (0.81) | LMNABAZ2BTRPV1MAPTGPX4 | |
| SCHEMBL12978505 | 0.84 | TRPV1 (0.66) | BAZ2BTRPV1KMT2AMEN1MAPT | |
| SCHEMBL5375005 | 0.83 | BAZ2B (0.64) | BAZ2BTRPV1KMT2AMEN1MAPT | |
| SCHEMBL21731891 | 0.80 | TRPV1 (0.64) | BAZ2BTRPV1 | |
| SCHEMBL21731973 | 0.80 | HDAC6 (0.59) | BAZ2BTRPV1KMT2AMEN1MAPT | |
| SCHEMBL5264982 | 0.79 | BAZ2B (0.59) | BAZ2BTRPV1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824821-A2 | CARBAZOLE, CARBOLINE AND INDOLE DERIVATIVES USEFUL IN THE INHIBITION OF VEGF PRODUCTION | PTC Therapeutics, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006058088-A2 | CARBAZOLE, CARBOLINE AND INDOLE DERIVATIVES USEFUL IN THE INHIBITION OF VEGF PRODUCTION | PTC THERAPEUTICS, INC. (US) | 2006-06-01 | — | — | WO | disclosed |