Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.47 |
| ▸ | JAK1 | P23458 | 8/20 | 0.47 |
| ▸ | TYK2 | P29597 | 8/20 | 0.47 |
| ▸ | JAK3 | P52333 | 8/20 | 0.47 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 7/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318313 | 0.91 | ITK (0.47) | JAK2JAK1TYK2JAK3ITK | |
| SCHEMBL5315393 | 0.86 | JAK2 (0.43) | JAK2JAK1TYK2JAK3ITK | |
| SCHEMBL5318212 | 0.81 | JAK2 (0.49) | JAK2JAK1TYK2JAK3ITK | |
| SCHEMBL5318305 | 0.79 | JAK2 (0.59) | JAK2JAK1TYK2JAK3CNR2 | |
| SCHEMBL5317039 | 0.77 | ITK (0.46) | ITKCNR2HRH3CNR1 | |
| SCHEMBL5318329 | 0.76 | ITK (0.51) | ITKCNR2HRH3 | |
| SCHEMBL5318349 | 0.76 | USP30 (0.45) | JAK2JAK1TYK2JAK3ITK | |
| SCHEMBL5315360 | 0.75 | ITK (0.43) | ITKCNR2CNR1 | |
| SCHEMBL5317545 | 0.73 | ITK (0.44) | ITKCNR2CNR1 | |
| SCHEMBL5318216 | 0.73 | ITK (0.43) | ITKCNR2ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |