Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4329517 | 0.86 | CNR1 (0.45) | P2RX7MAPK8METERCC1ERCC4 | |
| SCHEMBL3568253 | 0.84 | P2RX7 (0.53) | P2RX7MAOBGSK3BMEN1KMT2A | |
| SCHEMBL626266 | 0.82 | P2RX7 (0.49) | P2RX7MAOBGSK3BMEN1KMT2A | |
| SCHEMBL5315312 | 0.82 | P2RX7 (0.52) | P2RX7MAOBGSK3BMEN1KMT2A | |
| SCHEMBL23482150 | 0.79 | P2RX7 (0.56) | P2RX7MAOBMEN1KMT2AKCNA5 | |
| SCHEMBL18887627 | 0.79 | P2RX7 (0.50) | P2RX7MAOBERCC1ERCC4 | |
| SCHEMBL30259905 | 0.79 | P2RX7 (0.56) | P2RX7MAOBMEN1KMT2AKCNA5 | |
| SCHEMBL23981793 | 0.79 | P2RX7 (0.53) | P2RX7MAOBGSK3BMEN1KMT2A | |
| SCHEMBL4032263 | 0.79 | P2RX7 (0.53) | P2RX7MAOBGSK3BMEN1KMT2A | |
| SCHEMBL4243583 | 0.79 | P2RX7 (0.47) | P2RX7MAOBGSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |