Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315148 | 0.83 | POLB (0.56) | POLBCASP6MAPTCYP2C19KDM4E | |
| SCHEMBL1168399 | 0.79 | GAA (0.35) | POLBCASP6KDM4EMEN1KMT2A | |
| SCHEMBL1168607 | 0.76 | POLB (0.39) | POLBCASP6MAPTCYP2C19KDM4E | |
| SCHEMBL1168265 | 0.74 | GAA (0.40) | POLBCASP6MAPTKDM4EALDH1A1 | |
| SCHEMBL12863056 | 0.68 | CYP1A2 (0.41) | POLBCASP6CYP2C19KDM4EKMT2A | |
| SCHEMBL29606528 | 0.68 | NR1H2 (0.37) | POLBCASP6KDM4EALDH1A1GAA | |
| SCHEMBL28611913 | 0.68 | NR1H2 (0.37) | POLBCASP6KDM4EALDH1A1GAA | |
| SCHEMBL12863055 | 0.66 | KMT2A (0.36) | POLBCYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL1292089 | 0.66 | POLB (0.56) | POLBCASP6MAPTALDH1A1GAA | |
| SCHEMBL12863048 | 0.66 | PTGS2 (0.37) | POLBCASP6CYP2C19KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773835-B1 | PYRIDO-PYRIDO-PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, THERAPEUTIC USE THEREOF FOR TREATING CANCER | SANOFI SA (FR) | 2014-09-24 | — | — | EP | disclosed |
| CN-101124223-A | Pyrido-pyrimidine derivatives, their preparation and their therapeutic use | SANOFI AVENTIS (FR) | 2008-02-13 | — | — | CN | disclosed |
| EP-1773835-A2 | PYRIDO-PYRIDO-PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, THERAPEUTIC USE THEREOF FOR TREATING CANCER | Sanofi-Aventis (FR) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006016067-A2 | PYRIDO-PYRIDO PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, THERAPEUTIC USE THEREOF FOR TREATING CANCER | SANOFI-AVENTIS (FR) | 2006-02-16 | — | — | WO | disclosed |