Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316196 | 0.91 | KCNH2 (0.48) | KCNH2HRH3USP30HRH2HRH1 | |
| SCHEMBL5316515 | 0.90 | KCNH2 (0.45) | KCNH2HRH3HTR2AKMT2A | |
| SCHEMBL5316328 | 0.86 | KCNH2 (0.55) | KCNH2HRH3HRH2HRH1HTR2A | |
| SCHEMBL5336447 | 0.85 | KCNH2 (0.46) | KCNH2HRH3 | |
| SCHEMBL4130153 | 0.83 | KCNH2 (0.51) | KCNH2HRH3USP30HRH2HRH1 | |
| SCHEMBL4133463 | 0.83 | KCNH2 (0.54) | KCNH2HRH3USP30HRH2HRH1 | |
| SCHEMBL5315301 | 0.83 | KCNH2 (0.48) | KCNH2HTR2AKMT2A | |
| SCHEMBL5316576 | 0.83 | ENPP2 (0.43) | KCNH2ENPP2P2RX7USP30JAK2 | |
| SCHEMBL5314502 | 0.82 | HTT (0.41) | KCNH2ENPP2P2RX7CHRM4KMT2A | |
| SCHEMBL4669350 | 0.82 | KCNH2 (0.49) | KCNH2HRH3USP30HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |