Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15741796 | 0.84 | HPGD (0.44) | ALDH1A1KMT2ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL14266823 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KMT2ATDP1MEN1RAB9A | |
| SCHEMBL4579300 | 0.82 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2HPGDMAPK1HTT | |
| SCHEMBL4581018 | 0.80 | CYP1A2 (0.48) | ALDH1A1KMT2AMEN1HPGDMAPK1 | |
| SCHEMBL14266821 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KMT2ATDP1MEN1RAB9A | |
| SCHEMBL4579596 | 0.79 | ALDH1A1 (0.46) | ALDH1A1KMT2ATDP1MEN1RAB9A | |
| SCHEMBL15741702 | 0.78 | MEN1 (0.55) | ALDH1A1KMT2ATDP1MEN1SMN1; SMN2 | |
| SCHEMBL4580115 | 0.78 | HPGD (0.47) | ALDH1A1RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL14286997 | 0.77 | ALDH1A1 (0.44) | ALDH1A1KMT2ATDP1MEN1RAB9A | |
| SCHEMBL4581265 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KMT2ATDP1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773834-A2 | 2, 8-DISUBSTITUTED NAPHTHYRIDINE DERIVATIVES | Serenex, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006017672-A2 | 2, 8-DISUBSTITUTED NAPHTHYRIDINE DERIVATIVES | SERENEX INC. (US) | 2006-02-16 | — | — | WO | disclosed |