Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095343 | 0.88 | EGFR (0.62) | EGFRERBB2KDR | |
| SCHEMBL1105401 | 0.88 | EGFR (0.62) | EGFRERBB2KDR | |
| SCHEMBL5321400 | 0.87 | EGFR (0.70) | EGFRERBB2 | |
| SCHEMBL1094549 | 0.84 | EGFR (0.58) | EGFRERBB2KDR | |
| SCHEMBL1109052 | 0.84 | EGFR (0.58) | EGFRERBB2KDR | |
| SCHEMBL1105352 | 0.84 | EGFR (0.58) | EGFRERBB2KDR | |
| SCHEMBL4737217 | 0.83 | EGFR (0.57) | EGFRERBB2KDR | |
| SCHEMBL1105378 | 0.83 | EGFR (0.71) | EGFRERBB2KDR | |
| SCHEMBL1095766 | 0.83 | EGFR (0.65) | EGFRERBB2KDRRET | |
| SCHEMBL1105383 | 0.83 | EGFR (0.75) | EGFRERBB2KDRRETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081630-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-19 | — | — | WO | disclosed |