Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241112 | 0.91 | MAPK14 (0.42) | MAPK14MAPK11 | |
| SCHEMBL5209831 | 0.89 | MAPK14 (0.46) | MAPK14MAPK11MAOBPCSK9IDH1 | |
| SCHEMBL5239711 | 0.86 | MAPK14 (0.41) | MAPK14MAPK11 | |
| SCHEMBL5206441 | 0.85 | MAPK14 (0.48) | MAPK14MAPK11MAOBPCSK9 | |
| SCHEMBL5207048 | 0.81 | MAPK14 (0.44) | MAPK14MAPK11 | |
| SCHEMBL5206712 | 0.80 | MAPK8 (0.42) | MAPK14MAPK11IDH1 | |
| SCHEMBL5237786 | 0.78 | MAPK14 (0.37) | MAPK14MAPK11P2RX3MAPKAPK2 | |
| SCHEMBL5205934 | 0.78 | MAPK14 (0.46) | MAPK14MAPK11MAOB | |
| SCHEMBL5202629 | 0.77 | MAPK14 (0.45) | MAPK14MAPK11MAPKAPK2 | |
| SCHEMBL5206968 | 0.76 | MAPK14 (0.43) | MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802590-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | Pharmacia & Upjohn Company LLC (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040666-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-04-20 | — | — | WO | disclosed |