Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056576 | 0.85 | SMN1; SMN2 (0.40) | ALDH1A1RXFP1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5316508 | 0.76 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL28661629 | 0.75 | SMN1; SMN2 (0.65) | SMN1; SMN2KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL4055022 | 0.74 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KDM4EHPGDLMNA | |
| SCHEMBL99422 | 0.73 | KMT2A (0.65) | SMN1; SMN2KDM4ELMNAKMT2APOLB | |
| SCHEMBL4057323 | 0.72 | MAPT (0.44) | ALDH1A1RXFP1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5343442 | 0.70 | ALDH1A1 (0.44) | ALDH1A1RXFP1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5177389 | 0.68 | KDM4E (0.52) | ALDH1A1RXFP1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL99707 | 0.68 | KMT2A (0.51) | ALDH1A1KDM4EELANEKMT2A | |
| SCHEMBL5177676 | 0.68 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2KDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828199-A1 | THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS | F. Hoffmann-Roche AG (CH) | 2007-09-05 | — | — | EP | claimed |
| WO-2006063732-A1 | THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-06-22 | — | — | WO | claimed |
| EP-1828199-A1 | THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS | F. Hoffmann-Roche AG (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006063732-A1 | THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-06-22 | — | — | WO | disclosed |