Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.51 |
| ▸ | GAPDH | P04406 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | STAT6 | P42226 | 1/20 | 0.51 |
| ▸ | PI4KA | P42356 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.51 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800006 | 1.00 | LMNA (0.59) | LMNATP53HPGDDPP4MEN1 | |
| SCHEMBL2911993 | 0.85 | ADORA2A (0.60) | LMNATP53DPP4MEN1SLC28A1 | |
| SCHEMBL2911996 | 0.85 | ADORA2A (0.60) | LMNATP53DPP4MEN1SLC28A1 | |
| SCHEMBL13787625 | 0.85 | ADORA2A (0.60) | LMNATP53DPP4MEN1SLC28A1 | |
| SCHEMBL2912997 | 0.82 | ADORA2A (0.53) | LMNATP53DPP4MEN1SLC28A1 | |
| SCHEMBL20419308 | 0.81 | LMNA (0.60) | LMNATP53HPGDDPP4MEN1 | |
| SCHEMBL11132955 | 0.81 | LMNA (0.60) | LMNATP53HPGDDPP4MEN1 | |
| SCHEMBL12226010 | 0.80 | PI4KA (0.56) | LMNATP53ADORA3ADORA2AADORA2B | |
| SCHEMBL12200113 | 0.80 | PI4KA (0.56) | LMNATP53ADORA3ADORA2AADORA2B | |
| SCHEMBL1795540 | 0.80 | PI4KA (0.56) | LMNATP53ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848718-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006084281-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |