Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11374354 | 0.86 | KDM4E (0.81) | KDM4EPTGER4CNR2EHMT2ALDH1A1 | |
| SCHEMBL5317414 | 0.85 | HCAR3 (0.56) | KDM4EPTGER4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4259457 | 0.82 | KDM4E (0.56) | KDM4EPTGER4CNR2EHMT2ITK | |
| SCHEMBL5316676 | 0.81 | PTGER4 (0.58) | KDM4EPTGER4CNR2EHMT2ITK | |
| SCHEMBL9663682 | 0.81 | PTGER4 (0.62) | KDM4EPTGER4EHMT2ALDH1A1NPSR1 | |
| SCHEMBL1731129 | 0.77 | KDM4E (1.00) | KDM4EPTGER4ALDH1A1USP2NPSR1 | |
| SCHEMBL5375164 | 0.77 | KDM4E (0.54) | KDM4EPTGER4CNR2ALDH1A1NPSR1 | |
| SCHEMBL24688398 | 0.76 | KDM4E (0.74) | KDM4EPTGER4CNR2EHMT2ALDH1A1 | |
| SCHEMBL12380479 | 0.74 | KDM4E (0.52) | KDM4EPTGER4ALDH1A1HPGDTSHR | |
| SCHEMBL31551691 | 0.74 | KDM4E (0.65) | KDM4EPTGER4EHMT2USP2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |