Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408927 | 0.89 | SLC6A7 (0.58) | GAASLC6A7ALDH1A1HSD17B10KDM4E | |
| SCHEMBL3430961 | 0.85 | GAA (0.73) | GAAALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL3434504 | 0.83 | GAA (0.56) | GAASLC6A7ALDH1A1HSD17B10KDM4E | |
| SCHEMBL3429910 | 0.75 | SLC6A7 (0.62) | GAASLC6A7ALDH1A1HSD17B10KDM4E | |
| SCHEMBL3433399 | 0.74 | HSD17B10 (0.72) | GAASLC6A7ALDH1A1HSD17B10KDM4E | |
| SCHEMBL3430705 | 0.74 | SLC6A7 (0.57) | GAASLC6A7ALDH1A1HSD17B10KDM4E | |
| SCHEMBL2007249 | 0.72 | SCD (0.61) | SLC6A7GBA1 | |
| SCHEMBL27702525 | 0.72 | SLC6A7 (0.63) | SLC6A7ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL3432771 | 0.71 | SLC6A7 (0.57) | GAASLC6A7ALDH1A1HSD17B10KDM4E | |
| SCHEMBL4813898 | 0.71 | SLC6A7 (0.66) | SLC6A7ALDH1A1HSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851205-A2 | PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006086447-A2 | PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-08-17 | — | — | WO | disclosed |