SCHEMBL5318351

SCHEMBL5318351

CCCc1c(OCc2cccc(-c3ccccc3C#N)c2)ccc(C(C)=O)c1O.CCCc1c(OCc2cccc(Br)c2)ccc(C(C)=O)c1O

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYSLTR1 Q9Y271 10/20 0.48
GRM2 Q14416 8/20 0.48
MAOB P27338 3/20 0.45
MAOA P21397 2/20 0.45
CYSLTR2 Q9NS75 2/20 0.45
FFAR1 O14842 2/20 0.43
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CTSD P07339 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4937170 0.95 CYSLTR1 (0.52) CYSLTR1GRM2CYSLTR2FFAR1MAPT
SCHEMBL5318352 0.93 CYSLTR1 (0.44) CYSLTR1GRM2MAOBMAOACYSLTR2
SCHEMBL4945030 0.86 CYSLTR1 (0.60) CYSLTR1GRM2MAOBMAOACYSLTR2
SCHEMBL3166919 0.80 CYSLTR1 (0.62) CYSLTR1GRM2CYSLTR2MAPTCYP2C9
SCHEMBL10730502 0.79 CYSLTR1 (0.58) CYSLTR1GRM2CYSLTR2MAPTCYP2C9
SCHEMBL10751332 0.79 CYSLTR1 (0.58) CYSLTR1GRM2CYSLTR2MAPTCYP2C9
SCHEMBL3172561 0.79 CYSLTR1 (0.50) CYSLTR1GRM2CYSLTR2MAPTCYP2C9
SCHEMBL3168116 0.78 CYSLTR1 (0.49) CYSLTR1GRM2CYSLTR2MAPTCYP2C9
SCHEMBL3174134 0.77 CYSLTR1 (0.51) CYSLTR1GRM2CYSLTR2MAPTCYP2C9
SCHEMBL2895915 0.76 CYSLTR1 (0.47) CYSLTR1GRM2CYSLTR2MAPTCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773774-A2 HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS Merck & Co., Inc. (US) 2007-04-18 EP disclosed
WO-2006014918-A2 HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS MERCK & CO., INC. (US) 2006-02-09 WO disclosed