SCHEMBL5318352

SCHEMBL5318352

CCCc1c(OCc2cccc(-c3ccccc3C#N)c2)ccc(C(C)=O)c1O.CCCc1c(OCc2cccc(Br)c2)ccc(CC=O)c1O

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYSLTR1 Q9Y271 10/20 0.44
GRM2 Q14416 8/20 0.44
CYSLTR2 Q9NS75 2/20 0.40
MAOB P27338 3/20 0.39
MAOA P21397 2/20 0.39
FFAR1 O14842 1/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.38
KMT2A Q03164 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CTSD P07339 1/20 0.37
PDCD1 Q15116 1/20 0.36
CD274 Q9NZQ7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5318351 0.93 CYSLTR1 (0.48) CYSLTR1GRM2CYSLTR2MAOBMAOA
SCHEMBL4937170 0.88 CYSLTR1 (0.52) CYSLTR1GRM2CYSLTR2FFAR1CYP1A2
SCHEMBL4945030 0.79 CYSLTR1 (0.60) CYSLTR1GRM2CYSLTR2MAOBMAOA
SCHEMBL3166919 0.74 CYSLTR1 (0.62) CYSLTR1GRM2CYSLTR2CYP1A2MAPT
SCHEMBL10730502 0.73 CYSLTR1 (0.58) CYSLTR1GRM2CYSLTR2CYP1A2MAPT
SCHEMBL10751332 0.73 CYSLTR1 (0.58) CYSLTR1GRM2CYSLTR2CYP1A2MAPT
SCHEMBL3172561 0.73 CYSLTR1 (0.50) CYSLTR1GRM2CYSLTR2CYP1A2MAPT
SCHEMBL3168116 0.72 CYSLTR1 (0.49) CYSLTR1GRM2CYSLTR2CYP1A2MAPT
SCHEMBL3174134 0.72 CYSLTR1 (0.51) CYSLTR1GRM2CYSLTR2MEN1MAPT
SCHEMBL4943873 0.70 CYSLTR1 (0.58) CYSLTR1GRM2CYSLTR2CYP1A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773774-A2 HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS Merck & Co., Inc. (US) 2007-04-18 EP disclosed
WO-2006014918-A2 HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS MERCK & CO., INC. (US) 2006-02-09 WO disclosed