Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | HAT1 | O14929 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336551 | 0.95 | EPHX2 (0.52) | CD274CCR3KCNH2NAMPTEPHX2 | |
| SCHEMBL5317478 | 0.95 | CCR3 (0.54) | CD274CCR3DRD2DRD3NAMPT | |
| SCHEMBL5315274 | 0.94 | CD274 (0.53) | CD274CCR3KCNH2KCNJ1DRD2 | |
| SCHEMBL5315964 | 0.94 | CD274 (0.54) | CD274CCR3KCNH2DRD2DRD3 | |
| SCHEMBL5316471 | 0.91 | CD274 (0.56) | CD274CCR3KCNH2NAMPTMKNK1 | |
| SCHEMBL5319119 | 0.90 | CD274 (0.49) | CD274CCR3KCNH2DRD2DRD3 | |
| SCHEMBL5315542 | 0.90 | CD274 (0.47) | CD274CCR3KCNH2DRD2DRD3 | |
| SCHEMBL4125747 | 0.89 | KCNH2 (0.48) | CD274KCNH2KCNJ1DRD2DRD3 | |
| SCHEMBL5318392 | 0.89 | CD274 (0.58) | CD274CCR3KCNH2DRD2DRD3 | |
| SCHEMBL5318512 | 0.89 | CCR3 (0.57) | CD274CCR3DRD2DRD3NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |