Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318512 | 0.95 | CCR3 (0.57) | CD274CCR3DRD3DRD2NAMPT | |
| SCHEMBL5318987 | 0.94 | CD274 (0.56) | CD274CCR3DRD3DRD2MKNK1 | |
| SCHEMBL5316471 | 0.89 | CD274 (0.56) | CD274CCR3MKNK1MKNK2NAMPT | |
| SCHEMBL5336551 | 0.89 | EPHX2 (0.52) | CD274CCR3NAMPTKCNH2 | |
| SCHEMBL5317478 | 0.88 | CCR3 (0.54) | CD274CCR3DRD3DRD2NAMPT | |
| SCHEMBL5315274 | 0.88 | CD274 (0.53) | CD274CCR3DRD3DRD2MKNK1 | |
| SCHEMBL5318392 | 0.87 | CD274 (0.58) | CD274CCR3DRD3DRD2MKNK1 | |
| SCHEMBL2967590 | 0.86 | KCNH2 (0.44) | CD274CCR3KDM1AHDAC6DRD3 | |
| SCHEMBL5315942 | 0.85 | CD274 (0.56) | CD274CCR3DRD3DRD2MKNK1 | |
| SCHEMBL5317499 | 0.85 | CD274 (0.56) | CD274CCR3DRD3DRD2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |