SCHEMBL5319201

SCHEMBL5319201

COC(=O)c1nn(Cc2ccc(Cl)cc2F)c2cc(N)ccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
PMP22 Q01453 1/20 0.43
HIF1A Q16665 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
AKR1B1 P15121 1/20 0.39
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
GUCY1A1 Q02108 5/20 0.38
GUCY1B1 Q02153 5/20 0.38
GRM2 Q14416 1/20 0.37
PTGDR2 Q9Y5Y4 1/20 0.37
EGFR P00533 1/20 0.37
MCL1 Q07820 1/20 0.37
PTGER1 P34995 1/20 0.36
PDE4B Q07343 1/20 0.36
PDE11A Q9HCR9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1046218 0.93 CYP1A2 (0.47) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL5317360 0.90 PTGDR2 (0.39) CYP1A2CYP3A4CYP2D6CYP2C9GUCY1A1
SCHEMBL1049054 0.90 CYP1A2 (0.45) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL5320915 0.90 CYP1A2 (0.55) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL1044970 0.89 CYP1A2 (0.44) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL5318519 0.89 CYP1A2 (0.44) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL1048437 0.88 CYP1A2 (0.43) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL1050802 0.88 PTGER1 (0.46) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL5319096 0.88 CYP1A2 (0.45) CYP1A2CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL1049647 0.87 CYP1A2 (0.43) CYP1A2CYP3A4CYP2D6CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1786424-A2 LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT The University of Kansas (US) 2007-05-23 EP claimed
WO-2006023704-A2 LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT UNIVERSITY OF KANSAS (US) 2006-03-02 WO claimed