Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.82 |
| ▸ | TOP1 | P11387 | 18/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CASP1 | P29466 | 1/20 | 0.72 |
| ▸ | CASP7 | P55210 | 1/20 | 0.72 |
| ▸ | HBB | P68871 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060789 | 0.91 | MEN1 (0.82) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20471997 | 0.91 | MEN1 (0.82) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL26289731 | 0.91 | MEN1 (0.87) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL29354078 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL34018 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL29359781 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2828545 | 0.90 | MEN1 (0.81) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL13420265 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13529238 | 0.90 | TOP1 (0.84) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL29787648 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007095389-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH CAMPTOTHECINE N-OXIDE AND ANALOGS | NOVACEA, INC. (US) | 2007-08-23 | — | — | WO | claimed |
| EP-0137145-B1 | NEW CAMPTOTHECIN DERIVATIVES AND PROCESS FOR PREPARING SAME | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1988-04-27 | — | — | EP | disclosed |
| US-4604463-A | ANTITUMOR AGENTS | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1986-08-05 | — | — | US | disclosed |
| EP-0137145-A1 | New camptothecin derivatives and process for preparing same | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1985-04-17 | — | — | EP | disclosed |