Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.82 |
| ▸ | TOP1 | P11387 | 18/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CASP1 | P29466 | 1/20 | 0.72 |
| ▸ | CASP7 | P55210 | 1/20 | 0.72 |
| ▸ | HBB | P68871 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060789 | 1.00 | MEN1 (0.82) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15112720 | 0.92 | TOP1 (0.84) | MEN1KMT2ATOP1 | |
| SCHEMBL5319419 | 0.91 | MEN1 (0.82) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL13420265 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL29359781 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL29787648 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13529238 | 0.90 | TOP1 (0.84) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2828545 | 0.90 | MEN1 (0.81) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL34018 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL29354078 | 0.90 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10857147-B2 | SN-38 loaded iron crosslinked micelle and methods thereof | INTEZYNE TECHNOLOGIES, INC. (US) | 2020-12-08 | — | — | US | claimed |
| US-20190321353-A1 | SN-38 LOADED IRON CROSSLINKED MICELLE AND METHODS THEREOF | INTEZYNE TECHNOLOGIES, INC. | 2019-10-24 | — | — | US | claimed |
| US-10143689-B2 | SN-38 loaded iron crosslinked micelle and methods thereof | Interzyne Technologies, Inc. (US) | 2018-12-04 | — | — | US | claimed |
| WO-2018148432-A1 | SN-38 LOADED IRON CROSSLINKED MICELLE AND METHODS THEREOF | INTEZYNE TECHNOLOGIES, INC. (US) | 2018-08-16 | — | — | WO | claimed |
| US-10857147-B2 | SN-38 loaded iron crosslinked micelle and methods thereof | INTEZYNE TECHNOLOGIES, INC. (US) | 2020-12-08 | — | — | US | disclosed |
| US-20190321353-A1 | SN-38 LOADED IRON CROSSLINKED MICELLE AND METHODS THEREOF | INTEZYNE TECHNOLOGIES, INC. | 2019-10-24 | — | — | US | disclosed |
| US-10143689-B2 | SN-38 loaded iron crosslinked micelle and methods thereof | Interzyne Technologies, Inc. (US) | 2018-12-04 | — | — | US | disclosed |
| WO-2018148432-A1 | SN-38 LOADED IRON CROSSLINKED MICELLE AND METHODS THEREOF | INTEZYNE TECHNOLOGIES, INC. (US) | 2018-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190321353-A1 | SN-38 LOADED IRON CROSSLINKED MICELLE AND METHODS THEREOF | SLC40A1, FOLR1, SNX9 | MEN1 663/4885KMT2A 995/4885TOP1 74/4885 |
| US-10143689-B2 | SN-38 loaded iron crosslinked micelle and methods thereof | SLC40A1, FOLR1, SNX9 | MEN1 663/4885KMT2A 995/4885TOP1 74/4885 |
| US-10857147-B2 | SN-38 loaded iron crosslinked micelle and methods thereof | SLC40A1, FOLR1, SNX9 | MEN1 663/4885KMT2A 995/4885TOP1 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.