SCHEMBL5319435

SCHEMBL5319435

COc1cccc(CC2NCCC(=O)C2(C)C)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM4 P08173 2/20 0.49
DRD2 P14416 2/20 0.49
HTR7 P34969 2/20 0.49
EED O75530 1/20 0.46
KMT2A Q03164 2/20 0.43
CMA1 P23946 1/20 0.42
MEN1 O00255 1/20 0.40
HTR1B P28222 1/20 0.40
CHRM2 P08172 1/20 0.40
CHRM1 P11229 1/20 0.40
CHRM3 P20309 1/20 0.40
DDB1 Q16531 1/20 0.39
CRBN Q96SW2 1/20 0.39
DAO P14920 1/20 0.39
HTR1A P08908 1/20 0.39
SLC6A4 P31645 1/20 0.39
ALDH1A1 P00352 1/20 0.39
IDO1 P14902 1/20 0.38
AGXT P21549 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5322142 0.99 CHRM4 (0.48) CHRM4DRD2HTR7EEDKMT2A
Cadaverine Tartrate SCHEMBL7765577 0.90 CHRM4 (0.42) CHRM4DRD2HTR7EEDKMT2A
SCHEMBL7115062 0.86 CHRM4 (0.50) CHRM4DRD2HTR7EEDHTR1B
Hydrochloric Acid SCHEMBL5319527 0.85 CHRM4 (0.49) CHRM4DRD2HTR7EEDHTR1B
SCHEMBL3009582 0.84 GLA (0.46) KMT2AMEN1CRBNALDH1A1
SCHEMBL31013097 0.84 GLA (0.46) KMT2AMEN1CRBNALDH1A1
Hydrochloric Acid SCHEMBL11733745 0.83 GLA (0.45) KMT2AMEN1CRBNALDH1A1
SCHEMBL27468958 0.83 HTR7 (0.47) CHRM4DRD2HTR7EEDHTR1B
SCHEMBL8145005 0.81 HDAC8 (0.42) DDB1CRBN
SCHEMBL7764713 0.77 EED (0.51) CHRM4DRD2HTR7EEDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3887756-B2 2007-02-28 JP claimed
EP-0842153-B1 METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2\"R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE BOEHRINGER INGELHEIM PHARMA (DE) 2001-05-30 EP claimed
US-5945535-A Method of preparing norbenzomorphanes BOEHRINGER INGELHEIM KG (DE) 1999-08-31 US claimed
EP-0842153-A1 METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2\"R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE BOEHRINGER INGELHEIM KG (DE) 1998-05-20 EP claimed
WO-1997006146-A1 METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2'R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE BOEHRINGER INGELHEIM KG (DE) 1997-02-20 WO claimed
CN-1125053-C Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R, 5S, 2'R')-3'-hydroxy-2-(2-methoxypropyl)-5,..... BOEHRINGER INGELHEIM KG (DE) 2003-10-22 CN disclosed
EP-0842153-B1 METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2\"R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE BOEHRINGER INGELHEIM PHARMA (DE) 2001-05-30 EP disclosed
US-6140502-A Heat-based process for the re-racemisation of a (-)-2-phenylmethyl-3,3-dimethyl-piperidin-4-on derivative BOEHRINGER INGELHEIM KG (DE) 2000-10-31 US disclosed
US-6136980-A Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2\"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane BOEHRINGER INGELHEIM KG (DE) 2000-10-24 US disclosed
US-6054604-A Method of preparing norbenzomorphane as an intermediate BOEHRINGER INGELHEIM KG (DE) 2000-04-25 US disclosed
US-5945535-A Method of preparing norbenzomorphanes BOEHRINGER INGELHEIM KG (DE) 1999-08-31 US disclosed
CN-1190959-A New process for preparing pharmaceutically useful benzomorphane derivatives, particularly (-) - (1R,5S,2' ' -R) -3 ' -hydroxy-2- (2-methoxypropyl) -5, 9, 9-trimethyl-6, 7-benzomorphane intermediates, norbenzomorphane BOEHRINGER INGELHEIM KG (DE) 1998-08-19 CN disclosed
EP-0842153-A1 METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2\"R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE BOEHRINGER INGELHEIM KG (DE) 1998-05-20 EP disclosed
WO-1997006146-A1 METHOD OF PREPARING NORBENZOMORPHANE AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY USEFUL BENZOMORPHANE DERIVATIVES, IN PARTICULAR (-)-(1R,5S,2'R)-3'-HYDROXY-2-(2-METHOXYPROPYL)-5,9,9-TRIMETHYL-6,7-BENZOMORPHANE BOEHRINGER INGELHEIM KG (DE) 1997-02-20 WO disclosed