Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7718560 | 0.83 | PTPN11 (0.54) | PTPN11CTSBMAPTALDH1A1HTT | |
| SCHEMBL5259313 | 0.83 | GPR119 (0.57) | PTPN11CTSBMAPTALDH1A1HTT | |
| SCHEMBL390133 | 0.81 | GPR119 (0.68) | MAPTALDH1A1GPR119KMT2AMEN1 | |
| SCHEMBL5261119 | 0.80 | KDM4E (0.54) | PTPN11CTSBMAPTALDH1A1PTK2 | |
| SCHEMBL7719465 | 0.76 | MAPT (0.53) | CTSBMAPTALDH1A1HTTTP53 | |
| SCHEMBL23536097 | 0.74 | MAPT (0.58) | CTSBMAPTALDH1A1HTTTP53 | |
| SCHEMBL29931994 | 0.74 | MAPT (0.58) | CTSBMAPTALDH1A1HTTTP53 | |
| SCHEMBL30751569 | 0.73 | PTPN11 (0.57) | PTPN11MAPTALDH1A1TP53KMT2A | |
| SCHEMBL2491808 | 0.73 | MAPT (0.67) | PTPN11CTSBMAPTALDH1A1HTT | |
| SCHEMBL30751504 | 0.73 | PTPN11 (0.56) | PTPN11MAPTALDH1A1TP53PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | disclosed |