Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
| ▸ | MGMT | P16455 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.45 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2451247 | 0.86 | MAOB (0.48) | EGFRLMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2453751 | 0.85 | EGFR (0.46) | EGFRERBB2MAOAMAOB | |
| SCHEMBL2452662 | 0.85 | MGMT (0.49) | EGFRMGMTHTTCA12CA1 | |
| SCHEMBL2453807 | 0.84 | CDC7 (0.52) | EGFRHPGDCDC7DBF4ERBB2 | |
| SCHEMBL2451246 | 0.84 | RAB9A (0.52) | EGFRMAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL2450854 | 0.84 | MAP3K7 (0.51) | EGFRMGMTMAP3K7TAB1ERBB2 | |
| SCHEMBL2451281 | 0.84 | MAOB (0.50) | EGFRALDH1A1SMN1; SMN2ERBB2MAOA | |
| SCHEMBL2451011 | 0.82 | EGFR (0.39) | EGFRFFAR2MGMTCDK1CCNB1 | |
| SCHEMBL2454013 | 0.82 | MAOB (0.48) | EGFRHTTMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6362726 | 0.81 | MGMT (0.63) | MGMTCDK1CCNB1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109783-A2 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-09-27 | — | — | WO | claimed |
| WO-2007109783-A2 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-09-27 | — | — | WO | disclosed |