Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316323 | 0.86 | ITK (0.48) | POLBHDAC6HRH3ITKCNR2 | |
| SCHEMBL5317398 | 0.80 | ITK (0.49) | ITKMRGPRX2CNR2 | |
| SCHEMBL5318430 | 0.80 | ITK (0.49) | HRH3ITKCNR2 | |
| SCHEMBL5315622 | 0.80 | TLR9 (0.46) | ADORA2AADORA1TLR9TLR8TLR7 | |
| SCHEMBL5315400 | 0.79 | FLT3 (0.48) | TLR9TLR8TLR7ITK | |
| SCHEMBL5320783 | 0.79 | ITK (0.47) | ITKMRGPRX2 | |
| SCHEMBL5316334 | 0.78 | CNR2 (0.52) | ITKCNR2 | |
| SCHEMBL4258690 | 0.78 | HDAC6 (0.53) | POLBHDAC6MEN1KMT2A | |
| SCHEMBL5317039 | 0.78 | ITK (0.46) | HDAC6HRH3ITKCNR2 | |
| SCHEMBL5316556 | 0.78 | HDAC6 (0.63) | ADORA2AADORA1HDAC6HRH3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |