Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2978492 | 0.90 | HDAC1 (0.45) | SIRT2TRPV1BAZ2BCHEK1DYRK1A | |
| SCHEMBL2980504 | 0.90 | CYP17A1 (0.43) | SIRT2TRPV1BAZ2BMEN1KMT2A | |
| SCHEMBL2986268 | 0.87 | BAZ2B (0.46) | SIRT2BAZ2BMEN1KMT2AKDM4E | |
| SCHEMBL2973481 | 0.86 | SIRT2 (0.44) | SIRT2TRPV1BAZ2BMEN1KMT2A | |
| SCHEMBL2970389 | 0.86 | SIRT2 (0.43) | SIRT2BAZ2BMEN1KMT2AKDM4E | |
| SCHEMBL2978678 | 0.85 | SIRT2 (0.43) | SIRT2TRPV1BAZ2BMEN1KMT2A | |
| SCHEMBL2980531 | 0.85 | SIRT2 (0.43) | SIRT2KITBAZ2BMEN1KMT2A | |
| SCHEMBL2980630 | 0.84 | SIRT2 (0.42) | SIRT2BAZ2BMEN1KMT2AKDM4E | |
| SCHEMBL2975804 | 0.84 | SIRT2 (0.42) | SIRT2BAZ2BMEN1KMT2AKDM4E | |
| SCHEMBL5374091 | 0.84 | BAZ2B (0.53) | SIRT2BAZ2BMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851219-A1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE | Miikana Therapeutics, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006088949-A1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE | MIIKANA THERAPEUTICS, INC. (US) | 2006-08-24 | — | — | WO | disclosed |