Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4939629 | 0.90 | BAZ2B (0.53) | BAZ2BSIRT2HTR6HTR1AHTR2C | |
| SCHEMBL2986268 | 0.86 | BAZ2B (0.46) | BAZ2BMAPTLMNASIRT2KDM4E | |
| SCHEMBL2973481 | 0.85 | SIRT2 (0.44) | BAZ2BMAPTLMNASIRT2KDM4E | |
| SCHEMBL2970389 | 0.84 | SIRT2 (0.43) | BAZ2BMAPTLMNASIRT2KDM4E | |
| SCHEMBL5320029 | 0.84 | SIRT2 (0.43) | BAZ2BMAPTSIRT2KDM4EALDH1A1 | |
| SCHEMBL2980531 | 0.84 | SIRT2 (0.43) | BAZ2BMAPTSIRT2KDM4EALDH1A1 | |
| SCHEMBL2978678 | 0.84 | SIRT2 (0.43) | BAZ2BMAPTLMNASIRT2KDM4E | |
| SCHEMBL5374096 | 0.83 | BAZ2B (0.51) | BAZ2BSIRT2HTR6HTR1AHTR2C | |
| SCHEMBL5316177 | 0.83 | AURKA (0.41) | BAZ2BMAPTTHRBTP53SIRT2 | |
| SCHEMBL2980630 | 0.83 | SIRT2 (0.42) | BAZ2BMAPTTHRBLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851219-A1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE | Miikana Therapeutics, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006088949-A1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE | MIIKANA THERAPEUTICS, INC. (US) | 2006-08-24 | — | — | WO | disclosed |