Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.80 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.80 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.64 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095949 | 0.89 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL5524423 | 0.84 | EGFR (0.80) | EGFRERBB2ERBB3ERBB4GAK | |
| SCHEMBL14467425 | 0.84 | EGFR (0.76) | EGFRERBB2ERBB3ERBB4GAK | |
| SCHEMBL2748379 | 0.82 | EGFR (0.69) | EGFRERBB2ERBB3ERBB4GAK | |
| SCHEMBL1105295 | 0.82 | EGFR (0.82) | EGFRERBB2ERBB3ERBB4GAK | |
| SCHEMBL28347182 | 0.82 | EGFR (0.74) | EGFRERBB2ERBB3ERBB4GAK | |
| SCHEMBL5002100 | 0.82 | EGFR (0.82) | EGFRERBB2ERBB3ERBB4GAK | |
| SCHEMBL5002106 | 0.82 | EGFR (0.82) | EGFRERBB2ERBB3ERBB4GAK | |
| SCHEMBL233913 | 0.82 | EGFR (0.77) | EGFRERBB2ERBB3ERBB4GAK | |
| SCHEMBL12694678 | 0.80 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081630-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-19 | — | — | WO | disclosed |