Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 7/20 | 0.42 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | HTR1D | P28221 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5340176 | 0.86 | KDM4E (0.39) | KDM4EHPGDHRH4HTR1BHTR1A | |
| SCHEMBL5322764 | 0.84 | HRH4 (0.45) | KDM4EHRH4HTR1BALDH1A1DRD2 | |
| SCHEMBL14437521 | 0.79 | HTR1B (0.49) | KDM4EHTR1BHTR1AHTR1DALDH1A1 | |
| SCHEMBL5322699 | 0.79 | HTR1B (0.58) | HTR1BHTR1AHTR1DALDH1A1TSHR | |
| SCHEMBL14437529 | 0.79 | HTR1B (0.58) | HPGDHTR1BHTR1AHTR1DALDH1A1 | |
| SCHEMBL14437397 | 0.77 | HTR1B (0.57) | KDM4EHPGDHTR1BHTR1AHTR1D | |
| SCHEMBL14437524 | 0.77 | HTR1B (0.56) | HPGDHTR1BHTR1AHTR1DALDH1A1 | |
| SCHEMBL14437849 | 0.77 | HTR1B (0.56) | HTR1BHTR1AHTR1DALDH1A1TSHR | |
| SCHEMBL14437526 | 0.76 | HTR1B (0.46) | KDM4EHTR1BHTR1AHTR1DALDH1A1 | |
| SCHEMBL4988681 | 0.76 | HTR1B (0.63) | KDM4EHPGDHRH4HTR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007097697-A1 | THERAPEUTIC QUINOLINE COMPOUNDS THAT ARE 5HT1B MODULATORS | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | WO | claimed |
| WO-2007097697-A1 | THERAPEUTIC QUINOLINE COMPOUNDS THAT ARE 5HT1B MODULATORS | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | WO | disclosed |