Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14437848 | 0.85 | WDR5 (0.45) | HRH4HTR1BKDM4ESETD2MEN1 | |
| SCHEMBL5320569 | 0.84 | KDM4E (0.46) | HRH4HTR1BGPR35KDM4EDRD3 | |
| SCHEMBL4988305 | 0.78 | HTR1B (0.61) | HRH4HTR1BGPR35KDM4EDRD3 | |
| Hydrochloric Acid SCHEMBL4982786 | 0.77 | HTR1B (0.60) | HRH4HTR1BGPR35KDM4EDRD3 | |
| SCHEMBL5344999 | 0.73 | HTR2C (0.39) | HRH4KDM4EDRD3DRD2DRD4 | |
| SCHEMBL4988681 | 0.71 | HTR1B (0.63) | HRH4HTR1BGPR35KDM4EDRD3 | |
| SCHEMBL5340176 | 0.70 | KDM4E (0.39) | HRH4HTR1BKDM4ELMNAALDH1A1 | |
| SCHEMBL2430511 | 0.68 | KDM4E (0.56) | KDM4EMEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL50448 | 0.68 | IDO1 (0.50) | GPR35KDM4EMEN1LMNAKMT2A | |
| SCHEMBL14437851 | 0.68 | HTR1B (0.59) | HTR1BSETD2MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007097697-A1 | THERAPEUTIC QUINOLINE COMPOUNDS THAT ARE 5HT1B MODULATORS | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | WO | claimed |
| WO-2007097697-A1 | THERAPEUTIC QUINOLINE COMPOUNDS THAT ARE 5HT1B MODULATORS | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | WO | disclosed |