Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.58 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.42 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.38 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.38 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.38 |
| ▸ | GSR | P00390 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL5320793 | 1.00 | SLC7A5 (0.58) | SLC7A5SLC1A1SLC1A3SLC1A2GLRA1 | |
| Valine SCHEMBL28338552 | 0.93 | SLC7A5 (0.50) | SLC7A5SLC1A1SLC1A3SLC1A2GLRA1 | |
| Valine SCHEMBL23610284 | 0.93 | SLC7A5 (0.50) | SLC7A5SLC1A1SLC1A3SLC1A2GLRA1 | |
| Valine SCHEMBL2323247 | 0.92 | SLC7A5 (0.68) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Valine SCHEMBL723256 | 0.92 | SLC7A5 (0.68) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Valine SCHEMBL723255 | 0.92 | SLC7A5 (0.68) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Glutamic Acid SCHEMBL6465269 | 0.90 | CYP1A2 (0.56) | SLC7A5SLC1A1SLC1A3SLC1A2GRIK1 | |
| Valine SCHEMBL8845240 | 0.88 | SLC7A5 (0.62) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Valine SCHEMBL16570726 | 0.88 | SLC7A5 (0.75) | SLC7A5SLC1A1SLC1A3SLC1A2GLRA1 | |
| Valine SCHEMBL2586572 | 0.88 | SLC7A5 (0.75) | SLC7A5SLC1A1SLC1A3SLC1A2GLRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109963870-A | ANTI-B7-H3 ANTIBODIES AND ANTIBODY DRUG CONJUGATES | 艾伯维公司 | 2019-07-02 | — | — | CN | disclosed |
| CN-109641962-A | anti-B7-H3 antibodies and antibody drug conjugates | 艾伯维公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-109562169-A | anti-CD 98 antibodies and antibody drug conjugates | 艾伯维公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109562170-A | anti-CD 98 antibodies and antibody drug conjugates | 艾伯维公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109562168-A | anti-CD 98 antibodies and antibody drug conjugates | 艾伯维公司 | 2019-04-02 | — | — | CN | disclosed |
| WO-2007103288-A2 | ENGINEERED ANTIBODY DRUG CONJUGATES | SEATTLE GENETICS, INC. (US) | 2007-09-13 | — | — | WO | disclosed |
| US-6090250-A | CAPILLARY ELECTROPHORESIS CHROMATOGRAPHY USING AN ANIONIC SURFACTANT HAVING A HYDROPHOBIC TAIL IN A CHANNEL WITH AN ELECTROLYTE SOLUTION WHERE THE COMPOUND, E.G., ASPARTAME, IS INJECTED, VOLTAGE APPLIED AND MICELLES FORMED; HIGH SPEED | WATERS INVESTMENTS LIMITED (US) | 2000-07-18 | — | — | US | disclosed |