Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 2/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL23610284 | 1.00 | SLC7A5 (0.50) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Threonine SCHEMBL9228477 | 0.95 | USP2 (0.41) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Threonine SCHEMBL28173644 | 0.95 | USP2 (0.41) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Threonine SCHEMBL2076959 | 0.95 | USP2 (0.41) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Threonine SCHEMBL21332591 | 0.95 | USP2 (0.41) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Valine SCHEMBL4409187 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Valine SCHEMBL5320799 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Valine SCHEMBL4409201 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Valine SCHEMBL5320793 | 0.93 | SLC7A5 (0.58) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 | |
| Valine SCHEMBL7869516 | 0.93 | PTGS1 (0.46) | SLC7A5SLC1A1SLC1A3SLC1A2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573615-B | Polyvinyl alcohol degrading enzyme and method for producing same | 株式会社林原 | 2024-03-08 | — | — | CN | disclosed |
| CN-110573615-A | Polyvinyl alcohol degrading enzyme and method for producing same | 株式会社林原 | 2019-12-13 | — | — | CN | disclosed |