Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.48 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4345537 | 0.86 | TGFBR1 (0.49) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4339432 | 0.85 | TGFBR1 (0.49) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4343647 | 0.85 | TGFBR1 (0.48) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4343661 | 0.83 | TGFBR1 (0.48) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4332563 | 0.82 | TGFBR1 (0.47) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4347697 | 0.79 | TGFBR1 (0.61) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4348634 | 0.79 | TGFBR1 (0.52) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4339351 | 0.78 | TGFBR1 (0.51) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4334259 | 0.78 | TGFBR1 (0.63) | TGFBR1ACVR1BMAPK14RIPK2TDP1 | |
| SCHEMBL4338419 | 0.77 | TGFBR1 (0.54) | TGFBR1ACVR1BMAPK14RIPK2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |