Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.42 |
| ▸ | PDE4A | P27815 | 7/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.42 |
| ▸ | PTH1R | Q03431 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5352183 | 0.84 | PTH1R (0.36) | PDE4BPDE4APDE4CPDE4DPTH1R | |
| SCHEMBL5351487 | 0.83 | PTH1R (0.36) | PDE4BPDE4APDE4CPDE4DPTH1R | |
| SCHEMBL5354276 | 0.82 | PTH1R (0.34) | PDE4BPDE4APDE4CPDE4DPTH1R | |
| SCHEMBL5361939 | 0.81 | PDE4A (0.40) | PDE4BPDE4APDE4CPDE4DPTH1R | |
| SCHEMBL5325236 | 0.80 | PTH1R (0.46) | PDE4BPDE4APDE4CPDE4DPTH1R | |
| SCHEMBL5349032 | 0.76 | PTH1R (0.49) | PDE4BPDE4APDE4CPDE4DPTH1R | |
| SCHEMBL5326236 | 0.76 | PTH1R (0.41) | PTH1R | |
| SCHEMBL5326300 | 0.72 | PTH1R (0.48) | PDE4BPDE4APDE4CPDE4DPTH1R | |
| SCHEMBL5345828 | 0.71 | PTH1R (0.47) | PDE4BPDE4APDE4CPDE4DPTH1R | |
| SCHEMBL5323094 | 0.70 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |