Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 4/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14466598 | 0.84 | PTPN2 (0.54) | HTTLMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL5348172 | 0.77 | HDAC6 (0.48) | LMNAALDH1A1HDAC1HDAC6 | |
| SCHEMBL4900434 | 0.76 | DBH (0.39) | PTPRCPTPN2PTPN1 | |
| SCHEMBL3748551 | 0.76 | KDM4E (0.41) | HTTSMN1; SMN2TSHRALDH1A1PTPN2 | |
| SCHEMBL3732029 | 0.76 | KDM4E (0.36) | HTTTSHRALDH1A1PTPRCPTPN2 | |
| SCHEMBL3742667 | 0.76 | KDM4E (0.41) | HTTSMN1; SMN2TSHRALDH1A1HDAC1 | |
| SCHEMBL3733049 | 0.75 | PTPN1 (0.38) | PTPRCPTPN2PTPN1 | |
| SCHEMBL3741679 | 0.75 | PTPN1 (0.41) | LMNAPTPRCPTPN2PTPN1 | |
| SCHEMBL3742012 | 0.75 | KDM4E (0.40) | HTTSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL27696008 | 0.74 | PTPN1 (0.40) | PTPRCPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081755-A2 | INDOLE-BENZIMIDAZOLE AND INDAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | METABASIS THERAPEUTICS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |