Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5337560 | 0.85 | HDAC6 (0.55) | HDAC6HDAC1HDAC8HTR6ALDH1A1 | |
| SCHEMBL5348177 | 0.83 | HDAC6 (0.46) | HDAC6HDAC1HDAC8HTR6ALDH1A1 | |
| SCHEMBL5320495 | 0.78 | CACNB4 (0.45) | HDAC6HDAC1HDAC8 | |
| SCHEMBL5339333 | 0.78 | PLA2G2A (0.54) | HDAC6HDAC1HDAC8HTR6ALDH1A1 | |
| SCHEMBL5320908 | 0.77 | HTT (0.48) | HDAC6HDAC1ALDH1A1LMNA | |
| SCHEMBL5342941 | 0.77 | PLA2G2A (0.51) | HDAC6HDAC1HDAC8CHRNB2CHRNA7 | |
| SCHEMBL5317466 | 0.77 | HDAC1 (0.45) | HDAC6HDAC1HDAC8ALDH1A1LMNA | |
| SCHEMBL5320802 | 0.76 | HDAC1 (0.44) | HDAC6HDAC1HDAC8 | |
| SCHEMBL5324927 | 0.76 | HDAC1 (0.46) | HDAC6HDAC1HDAC8HTR6 | |
| SCHEMBL5320081 | 0.76 | PTPN2 (0.45) | HDAC6HDAC1HDAC8HTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081755-A2 | INDOLE-BENZIMIDAZOLE AND INDAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | METABASIS THERAPEUTICS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |