⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5862159 | 0.79 | — | — | |
| SCHEMBL4790392 | 0.77 | — | — | |
| SCHEMBL11737127 | 0.77 | — | — | |
| SCHEMBL676011 | 0.77 | — | — | |
| SCHEMBL11737125 | 0.77 | — | — | |
| SCHEMBL1445277 | 0.77 | — | — | |
| SCHEMBL18854875 | 0.77 | — | — | |
| Hydrogen Sulfide SCHEMBL11573446 | 0.75 | CYP2C19 (0.41) | — | |
| SCHEMBL4239372 | 0.73 | TRPA1 (0.47) | — | |
| SCHEMBL11217067 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4204407-B1 | PROCESS | GIVAUDAN SA (CH) | 2024-06-19 | — | — | EP | claimed |
| US-20230312506-A1 | PROCESS | GIVAUDAN SA (CH) | 2023-10-05 | — | — | US | claimed |
| EP-4204407-A1 | PROCESS | Givaudan SA (CH) | 2023-07-05 | — | — | EP | claimed |
| CN-116209659-A | Method | 奇华顿股份有限公司 | 2023-06-02 | — | — | CN | claimed |
| EP-4204407-B1 | PROCESS | GIVAUDAN SA (CH) | 2024-06-19 | — | — | EP | disclosed |
| US-20240139087-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | GIVAUDAN SA (CH) | 2024-05-02 | — | — | US | disclosed |
| US-20240132487-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | GIVAUDAN SA (CH) | 2024-04-25 | — | — | US | disclosed |
| EP-4291553-A1 | ORGANIC COMPOUNDS AS TRPM8 ACTIVATORS | Givaudan SA (CH) | 2023-12-20 | — | — | EP | disclosed |
| US-20230312506-A1 | PROCESS | GIVAUDAN SA (CH) | 2023-10-05 | — | — | US | disclosed |
| EP-4204407-A1 | PROCESS | Givaudan SA (CH) | 2023-07-05 | — | — | EP | disclosed |
| CN-116209659-A | Method | 奇华顿股份有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-114555594-A | Substituted azaheterocycles as TRMP8 modulators | 奇华顿股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2021074281-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | GIVAUDAN SA (CH) | 2021-04-22 | — | — | WO | disclosed |
| EP-1853626-A2 | AMYLOID-BINDING PEPTIDES, ANALOGUES AND USES THEREOF | Senexis Limited (GB) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006087550-A2 | AMYLOID-BINDING PEPTIDES, ANALOGUES AND USES THEREOF | SENEXIS LIMITED (GB) | 2006-08-24 | — | — | WO | disclosed |