Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.51 |
| ▸ | ABAT | P80404 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938530 | 0.86 | POLB (0.57) | POLBMAPK1TSHRALDH1A1TP53 | |
| SCHEMBL11328176 | 0.85 | GPR35 (0.56) | POLBMAPK1TSHRALDH1A1TP53 | |
| SCHEMBL30477507 | 0.85 | SNCA (0.62) | POLBMAPK1TSHRALDH1A1TP53 | |
| SCHEMBL69585 | 0.85 | SNCA (0.62) | POLBMAPK1TSHRALDH1A1TP53 | |
| SCHEMBL11002820 | 0.85 | MAPK1 (0.60) | POLBMAPK1TSHRALDH1A1TP53 | |
| SCHEMBL1736272 | 0.83 | POLB (0.62) | POLBMAPK1TSHRALDH1A1TP53 | |
| SCHEMBL3529585 | 0.81 | POLB (0.56) | POLBMAPK1TSHRALDH1A1TP53 | |
| SCHEMBL1025776 | 0.81 | POLB (0.56) | POLBMAPK1TSHRALDH1A1TP53 | |
| SCHEMBL346032 | 0.81 | POLB (0.65) | POLBMAPK1TSHRALDH1A1TP53 | |
| SCHEMBL7126615 | 0.81 | POLB (0.52) | POLBMAPK1TSHRALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8669249-B2 | Poly (ADP-ribose) polymerase (PARP) inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-03-11 | — | — | US | disclosed |
| US-8476455-B2 | 1-N-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them | LABORATOIRE THERAMEX (MC) | 2013-07-02 | — | — | US | disclosed |
| US-20120094992-A1 | POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-04-19 | — | — | US | disclosed |
| EP-2415767-A1 | Poly (ADP-ribose) Polymerase (PARP) Inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010111626-A2 | POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| US-20070112009-A1 | 1-N-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them | LABORATOIRE THERAMEX (MC) | 2007-05-17 | — | — | US | disclosed |
| US-5202336-A | Lipoxygenase inhibitors | BAYER AKTIENGESELLSCHAFT (DE) | 1993-04-13 | — | — | US | disclosed |
| US-5093340-A | Lipoxygenase enzyme inhibitors, antithrombolytic agents | BAYER AKTIENGESELLSCHAFT (DE) | 1992-03-03 | — | — | US | disclosed |
| US-5070096-A | ANTICOAGULANTS, LIPOXYGENASE INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-03 | — | — | US | disclosed |
| EP-0261539-B1 | SUBSTITUTED PHENYL-SULPHON AMIDES | BAYER AG (DE) | 1991-03-06 | — | — | EP | disclosed |
| EP-0261539-A2 | Substituted phenyl-sulphon amides | BAYER AG (DE) | 1988-03-30 | — | — | EP | disclosed |
| US-4317887-A | NUCLEOPHILIC-MODIFIED POLYACRYLAMIDE, POLYSTYRENE, AND DIVINYLBENZENE-STYRENE COPOLYMER; ION EXCHANGE RESINS; FIREPROOFING | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 1982-03-02 | — | — | US | disclosed |
| US-4215219-A | CHELATING AGENTS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 1980-07-29 | — | — | US | disclosed |
| US-4085261-A | CHELATING AGENT WITH A STYRENE POLYMER BACKBONE | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 1978-04-18 | — | — | US | disclosed |
| US-4016193-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JA) | 1977-04-05 | — | — | US | disclosed |
| US-3974110-A | Modification of polystyrene by Friedel-Crafts reaction with substituted halo ethyl benzenes and haloethylphenols to make supports for solid phase peptide synthesis | YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) | 1976-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094992-A1 | POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | PARP1, PARP2, PARP3 | POLB 25/4885MAPK1 2862/4885TSHR 4503/4885 |
| US-20070112009-A1 | 1-N-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them | H1-0, H1-5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | POLB 4013/4885MAPK1 2756/4885TSHR 2960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.